Protein name:
Mitogen-activated protein kinase kinase kinase 7 ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Identified in the TRIKA2 complex composed of MAP3K7, TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its repressed activity. Interacts with TRAF6 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with TAOK1 and TAOK2; interaction with TAOK2 interferes with MAP3K7 interaction with IKKA, thus preventing NF-kappa-B activation. Interacts with WDR34 (via WD domains). Interacts with RBCK1. Interacts with CYLD. Interacts with TGFBR1; induces MAP3K7 activation by TRAF6 (By similarity). Interacts with VRK2 and MAPK8IP1.
Function:
Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
Subcellular Location:
N/A
Protein Attributes:
50:
MSTASAASSS | SSSSASEMIE | APSQVLNFEE | IDYKEIEVEE | VVGRGAFGVV |
100:
CKAKWRAKDV | AIKQIESESE | RKAFIVELRQ | LSRVNHPNIV | KLYGACLNPV |
150:
CLVMEYAEGG | SLYNVLHGAE | PLPYYTAAHA | MSWCLQCSQG | VAYLHSMQPK |
200:
ALIHRDLKPP | NLLLVAGGTV | LKICDFGTAC | DIQTHMTNNK | GSAAWMAPEV |
250:
FEGSNYSEKC | DVFSWGIILW | EVITRRKPFD | EIGGPAFRIM | WAVHNGTRPP |
300:
LIKNLPKPIE | SLMTRCWSKD | PSQRPSMEEI | VKIMTHLMRY | FPGADEPLQY |
350:
PCQYSDEGQS | NSATSTGSFM | DIASTNTSNK | SDTNMEQVPA | TNDTIKRLES |
400:
KLLKNQAKQQ | SDSGRLSLGA | SRGSSVESLP | PTSEGKRMSA | DMSEIEARIV |
450:
ATTAYTKPKR | GHRKTASFGN | ILDVPEIVIS | GNGQPRRRSI | QDLTVTGTEP |
500:
GQVSSRSSSP | SVRMITTSGP | TSEKPARSLP | WTPDDSTDTN | GSDNSIPMAY |
550:
LTLDHQLQPL | APCPNSKESM | AVFEQHCKMA | QEYMKVQTEI | ALLLQRKQEL |
600:
VAELDQDEKD | QQNTSRLVQE | HKKLLDENKS | LSTYYQQCKK | QLEVIRSQQQ |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Human
Mouse
ELISA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
ELISA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
ELISA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
ELISA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
CLIA Kit for Rat Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
Polyclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
Monoclonal Antibody for Rat Mitogen-activated protein kinase kinase kinase 7
Protein for Rat Mitogen-activated protein kinase kinase kinase 7
Protein for Rat Mitogen-activated protein kinase kinase kinase 7
Protein for Rat Mitogen-activated protein kinase kinase kinase 7
Protein for Rat Mitogen-activated protein kinase kinase kinase 7
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
"Amgen rat EST program."
Amgen EST program
Submitted (2003-04) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 28-331
tissue :
Hypothalamus .
tissue :
Prostate .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 351-606